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Over expression of Glo can suppress inflammatory responses M
2021-09-14
Over-expression of Glo-1 can suppress inflammatory responses. Methylglyoxal mediates vascular inflammation in human endothelial Wnt-C59 [33], indicating that Glo-1 may attenuate inflammation via eliminating methylglyoxal. Glo-1 knockdown mediated methylglyoxal accumulation provokes collagen express
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It has been suggested that the presence of
2021-09-13
It has been suggested that the presence of nutrient-sensing receptors and their natural ligands originating from different metabolic pathways in farm animals, are related to the critical outcome of metabolic-derived diseases in cattle (Mielenz, 2017). Thus, current article aimed to review the most r
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sto products The typical pharmacophore for GPR agonists cont
2021-09-13
The typical pharmacophore for GPR40 agonists contains four parts: head (acid moiety), central (phenyl ring), linker and tail (aromatic carbocyclic or heterocyclic ring) [20]. On the other hand, the chemical features that are required for the PPARγ agonists include hydrogen bond donors and acceptors
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The effect of GCK NES mutations on
2021-09-13
The effect of GCK-NES mutations on enzyme kinetics and protein stability might account for the hyperglycaemia that characterizes MODY2 patients, since reduced GCK activity would increase the threshold for glucose stimulated insulin release in beta-cells [31,37,49]. However, a more in depth functiona
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The active site of PS is located at the interior
2021-09-13
The active site of PS1 is located at the interior of its TM horseshoe-like fold (29) (Fig. 1). TM2 and TM6 serve as “doors” for substrate entry (30), as also observed in recent molecular dynamics (MD) simulations of the PS1 subunit (31). Recent coarse-grained (CG) and atomic simulations also showed
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The concentration of rapamycin that gave
2021-09-11
The concentration of rapamycin that gave half-maximal induction of the expression of HO-1 and Prx-1 mRNA in normal hepatocytes was 0.05 μM, with maximal induction at about 0.1 μM rapamycin. While, at rapamycin concentrations higher than 0.1 μM, the degree of enzyme induction decreased, elevated expr
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br Materials and methods br Results br
2021-09-11
Materials and methods Results Discussion Myocardium reperfusion injury contributes almost half of myocardial infarct size in myocardial infarction patients, and infarct size is closely correlated with the probability of developing Ramiprilat failure [1]. Despite this knowledge, myocardial
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The lactic acid receptor HCA is
2021-09-11
The lactic PPM-18 synthesis receptor HCA1 is primarily expressed in white and brown adipocytes 11, 12, 17, 18 (Table 1). Only relatively low expression levels of HCA1 have been described in several other tissues 16, 19, and it is not clear whether this is due to the presence of adipocytes in these
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br Regulation of Glu transporters The
2021-09-11
Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino Neochlorogenic acid calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include t
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Biochemical and genetic studies indicate that the endosomal
2021-09-11
Biochemical and genetic studies indicate that the endosomal sorting complex required for transport (ESCRT) machinery is crucial for Hh exovesicle packaging and morphogen gradient function 39., 43., 44.. In vertebrates, ESCRT proteins promote the release of Shh exovesicles to maintain progenitor cell
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br Materials and methods br
2021-09-11
Materials and methods Results Discussion Both EMT of the tubular epithelial parthenolide and the activation of fibroblasts are critical factors in the pathogenesis and progression of renal interstitial fibrosis. Accumulating evidence implicates EMT in the onset and pathogenesis of renal in
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The fact that GSK recognition of its
2021-09-11
The fact that GSK-3 recognition of its substrate involves pre-phosphorylation supports the rational for using synthetic phosphorylated peptides as substrate competitive inhibitors [57]. Phosphorylated peptides derived from the N-terminal pseudosubstrate sequence of GSK-3β were very weak inhibitors o
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Our study has some limitations
2021-09-11
Our study has some limitations. While our study provides data from a diverse multi-country setting, we did not have a sufficient sample size to investigate whether the relationship of micronutrients and Docetaxel with CD4 recovery differed by country. We relied on measurement of deficiencies based o
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C steroids and their glycosylation
2021-09-11
C21 steroids and their glycosylation products distribute widely in Asclepiadaceae plants. Their anticancer activities have been shown in different human cell lines and in vivo animal experiments [[27], [28], [29], [30], [31], [32]]. However, the mechanisms of their anticancer activities are still un
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Inflammasomes are multimeric protein complexes involved
2021-09-10
Inflammasomes are multimeric protein complexes involved in the host defense protecting activity against invading pathogens and in physiological aberrations such as cancer and auto-inflammatory, metabolic, and neurodegenerative diseases. Inflammasomes induce the inflammatory process by triggering the
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