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Magnetic interactions between metal ions are usually describ
2020-08-14
Magnetic interactions between metal ions are usually described by superexchange via intermediate ligands. Although the general principles of the superexchange mechanism are essentially the same for d and f ions, calculations of exchange parameters for lanthanides are more difficult than for transiti
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This study has several limitations First despite the
2020-08-14
This study has several limitations. First, despite the relatively large number of participants for a pharmacological neuroimaging study, sample sizes for examining the modulation of THC effects by COMT Phenformin were small. Therefore, these particular findings should be interpreted with caution an
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Phenylbenzofurans are a very important molecule skeleton due
2020-08-14
Phenylbenzofurans are a very important molecule skeleton due to their synthetic versatility and their proved pharmacological properties [2]. They are synthetic compounds in which an additional phenyl ring is present in any position of the benzofuran nucleus. This could be easily obtained possible by
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The archaea are a group of microorganisms
2020-08-14
The archaea are a group of microorganisms, and many belong to extremophiles, living in extreme environments, such as those with high temperatures [6], [7]. Methanocaldococcus jannaschii is a methane-producing archaea [8]. It grows at pressures of up to more than 200atm and at an optimum temperature
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The presence of external NAD P H dehydrogenases
2020-08-14
The presence of external NAD(P)H dehydrogenases (NDE) on the outer surface of the inner mitochondrial membrane enables the mitochondria to oxidize cytosolic NAD(P)H (Moller 2001). A porin (a voltage-dependent anion-selective channel, VDAC) that is abundant in the outer mitochondrial membrane permits
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DNA promoter hypermethylation is an important
2020-08-14
DNA promoter hypermethylation is an important mechanism in epigenetic modulation of gene expression.[16], [17], [18] When the promoter CpG island of a gene is hypermethylated, the transcription and its associated function of the gene will be subsequently altered.[19], [20], [21] In human cancers, we
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Gemcitabine br Materials and methods br Results and
2020-08-14
Materials and methods Results and discussion Conclusions Clitocypin is another member of the mycocypin family of cysteine protease inhibitors that is unique to Gemcitabine shown to exhibit strong insecticidal activity against Colorado potato beetle larvae. This effect is concentration depen
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In conclusion our work provides the preclinical evidence sho
2020-08-14
In conclusion, our work provides the preclinical evidence showing the potent in vivo efficacy of AT7519 on chemoresistant cancer Erlotinib Hydrochloride and its underlying mechanisms of action. Our work supports the biological rationale behind the clinical trials initiated with AT7519, particularly
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Our study has several limitations As this study was performe
2020-08-14
Our study has several limitations. As this study was performed at a single institution, it had a limited sample size and was not powered to detect specific differences in assay performance by organ group or waitlist status. In the two CMV seropositive subjects with potential passive antibodies, the
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In rodents Wang et al Wang and Tsirka b
2020-08-13
In rodents (Wang et al., 2003, Wang and Tsirka, 2005b, Zhu et al., 2012) and humans (Wang et al., 2011), the major forms of cell death after ICH are necrosis and apoptosis. In the perihematomal region of rodents, the number of necrotic and apoptotic cells peaks at 72h post-ICH (Matsushita et al., 20
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br Oxidoreductase like MEM for prodrug activation
2020-08-13
Oxidoreductase-like MEM for prodrug activation Future outlook Although MEM-mediated prodrug activation has been performed by different MEMs and prodrugs, and their effectiveness have been proved in vivo, only a few types of MEMs or prodrugs have been explored in prodrug activation until now [2
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Related with the studies by Zizza et
2020-08-13
Related with the studies by Zizza et al. described above [66], work by Ward et al. [68] suggested that the C2 domain of cPLA2α, which binds to zwitterionic membranes with high affinity in a Ca2+-dependent manner, has a high membrane remodeling activity, producing dramatic changes in membrane curvatu
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Additionally in the presented study both the NSE
2020-08-13
Additionally, in the presented study both the NSE values and MFI levels of the CD45−CD34 + CXCR7+ 1400w correlated positively with the inflammatory parameter – CRP. CXCR7 expression has been found to be enhanced during pathological processes such as inflammation and neoplasms (Janssens et al., 2017
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In the signaling cascade of innate immunity most of
2020-08-13
In the signaling cascade of innate immunity, most of the receptor proteins, adaptor proteins, and kinases are modified by ubiquitination to activate and transduce the downstream signaling for efficient production of the IFN and proinflammatory cytokines to combat the pathogens. For example, the K-63
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Our current understanding of nucleotide
2020-08-13
Our current understanding of nucleotide metabolism in has made it possible to identify numerous proteins which serve essential roles in the life cycle of the parasite. One such protein is thymidylate synthase-dihydrofolate reductase (TS-DHFR), a bifunctional enzyme which is necessary for the produc
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