• br Introduction Human endogenous retroviruses HERVs are gene

  2019-05-07

  

  Introduction Human endogenous retroviruses (HERVs) are genetic remnants of ancient retroviral infections of the germ line produced during primate evolution which are now transmitted vertically. To date, approximately 8% of the human genome is composed of such retroviral sequences [1]. Most HERVs

• br Results and discussion br Authorship contributions br Con

  2019-05-07

  

  Results and discussion Authorship contributions Conflict of interest Acknowledgments This work is supported by grants from the United States National Institutes of Health/National Cancer Institute: R01 CA098472 and R01 CA170334. We thank Dr. Dan Zhang and Andy Awwad for technical assista

• The ETV ABL fusion has been reported as a poor

  2019-05-07

  

  The ETV6-ABL1 fusion has been reported as a poor prognostic factor when found in acute leukemia (AML and ALL) and MDS. The prognostic significance of an ETV6/ABL1 chronic myeloproliferative neoplasm is less clear due to the paucity of cases and the lack of controlled clinical trials [5]. There is a

• The starting point is to

  2019-05-07

  

  The starting point is to address the huge gap in surveillance capabilities identified in 2014 by the WHO\'s first global report on surveillance of antimicrobial resistance. To address this perk kinase gap, WHO\'s action plan is being implemented in phases from early 2016 onwards, gathering informat

• Introduction Atrial fibrillation AF is

  2019-05-07

  

  Introduction Atrial fibrillation (AF) is a highly prevalent atrial arrhythmia that affects approximately 10% of individuals older than 75 years of age and tends to increase in prevalence with advancing age [1–3]. Although AF itself is not life threatening, it is a risk factor for stroke, and the AF

• br Remote technologies The platforms available for

  2019-05-07

  

  Remote technologies The platforms available for remote monitoring of ICDs differ. Wand-based (“inductive”) systems require patient-driven downloads relayed via telephone connections to tracking facilities [4,5]. These are becoming obsolete. This is because they demand coordination with a device c

• Introduction Bone metastases are a common manifestation of c

  2019-05-07

  

  Introduction Bone metastases are a common manifestation of cancer [1]. Most patients present with pain and impaired mobility, while others can develop complications such as pathological fractures and GSK1070916 of the spinal cord or cauda equina [2]. Many randomized studies have been conducted to d

• The finding that baseline VEGF in the Zamboney study was

  2019-05-06

  

  The finding that baseline VEGF in the Zamboney study was not associated with clinical outcomes are in somehow to other published studies. VEGF was previously shown to be associated with better treatment outcomes in metastatic breast cancer patients treated with bevacizumab [26,31]. This discrepancy

• Es pertinente mencionar que el enfoque

  2019-05-06

  

  Es pertinente mencionar que el enfoque metodológico desarrollado por la autora nos adentra en las preocupaciones centrales de estos tres intelectuales; nos presenta sus argumentos, su visión de México, del gobierno, de sus instituciones, su pasado y el devenir. De igual forma, se muestra a estos tre

• La Historia natural o moral de las Indias de Joseph

  2019-05-06

  

  5. La Historia natural o moral de las Indias de Joseph de Acosta (1540-1600), impresa en 1592, recoge con gran concisión y puntualidad hechos históricos al tiempo que explica los aspectos de la naturaleza que, desde su perspectiva, no han sido tratados en forma adecuada por las fuentes anteriores. E

• br Conflict of interest statement br Acknowledgments Funded

  2019-05-06

  

  Conflict of interest statement Acknowledgments Funded by the Division of Medical Oncology at Princess Margaret Hospital, Toronto, Canada. No pharmaceutical company funding was received. The authors acknowledge the roles of Esther Lee and Tazmin Usmani in trial coordination and Dr. Ranjeeta Mal

• br Conclusion Accumulating clinical data suggest the presenc

  2019-05-06

  

  Conclusion Accumulating clinical data suggest the presence of a genetic component in the pathogenesis of AF. In addition to the gene mutations identified in familial AF, the candidate gene approach and GWAS identified genetic risks in the non-familial form of AF. In multiple Western populations,

• The greater relative importance of indirect causes could be

  2019-05-06

  

  The greater relative importance of indirect causes could be a result of successful addressing of direct complications of pregnancy and childbirth, and of a change in risk factors and disease patterns. Indirect causes of death include the effects of pre-existing disorders, such as HIV infection, ment

• One of the lessons the global health community learned

  2019-05-06

  

  One of the lessons the global health c-Myc tag learned from its experience with HIV was the need to rapidly identify individuals who are eligible for treatment. Yet HCV is severely underdiagnosed ( Lancet Glob Health —The following sentence should have read “Alarmingly, almost half of both for ch

• Este nuevo orden de lo latinoamericano ha afectado

  2019-05-06

  

  Este nuevo orden de “lo latinoamericano” ha afectado también en el estatuto de otras disciplinas, entre ellas literatura comparada, estudios étnicos, latinidad norteamericana, Caribe, sociología, pensamiento teológico y hasta en una nueva dimensión hemisférica de los American Studies. Son muchas las

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