• br Approval statement br Role of the

  2019-04-19

  

  Approval statement Role of the funding source Conflict of interest Acknowledgments Introduction Osteosarcoma (OS) is the most common malignancy of bone, mainly affecting children, adolescents and young adults. According to the American Cancer Society, 750–900 new cases of OS are diagn

• In summary current evidence suggests that bone targeted agen

  2019-04-19

  

  In summary, current evidence suggests that bone-targeted agents reduce morbidity from metastatic disease to bone, and potentially improve quality of life in patients with metastatic breast cancer. As there are costs and potential adverse effects associated with these agents, care should be taken in

• Both breast cancer and MM cause osteolytic

  2019-04-19

  

  Both breast cancer and MM cause osteolytic lesions, inhibiting osteoblast differentiation and thereby tipping the balance in favour of osteoclastic activity. In contrast, prostate cancer predominantly causes osteoblastic bone disease. Interestingly, increased marrow adiposity has been associated wit

• Introduction Catheter ablation of accessory pathways APs can

  2019-04-19

  

  Introduction Catheter ablation of accessory pathways (APs) can be challenging depending on the location of the AP. Anteroseptal APs are rare but associated with lower success rates and higher incidence of atrioventricular (AV) block [1,2]. Data regarding the electrocardiographic and electrophysiolo

• En ella se muestran los criterios

  2019-04-18

  

  En ella se muestran los criterios sobre los que se acepta negociar en los diálogos de paz en La Habana. Fuera de estas reglas de juego para la negociación, se establecen puntos en común en ella y que según Aira: “Es indiscutible que el ‘Poder’ desempeña un papel fundamental dentro de la negociación”

• Interpretation Haitian children have unacceptable rates of

  2019-04-18

  

  Interpretation Haitian children have unacceptable rates of raised blood lead concentrations, with an unexplained disproportionate elevation in children living in the Centre department. Our findings suggest that routine, widespread screening, detailed investigation into modifiable risk factors, targe

• br Introduction Percutaneous transcatheter device

  2019-04-18

  

  Introduction Percutaneous transcatheter device closure of atrial septal defects (ASD) has become an effective alternative therapy to surgical repair in patients with secundum type ASD. Amplatzer ASD or ventricular septal defect (VSD) occluders were used for the closure of ASDs or VSDs, respective

• SQ 22536 If a structurally normal patient with polymorphic V

  2019-04-18

  

  If a structurally normal patient with polymorphic VT/VF storm has a completely normal baseline ECG, the possible diagnosis includes CPVT and idiopathic VF. CPVT is an inherited disorder of intracellular Ca2+ handling, which can cause polymorphic VT/VF storms [10]. Abnormal SR Ca2+ release from defec

• In addition we evaluated the

  2019-04-18

  

  In addition, we evaluated the left atrium–left ventricle contraction sequence caused by the interatrial conduction delay. When we performed AV sequential pacing using the nominal AV delay setting, left atrial contractions were significantly delayed and were almost simultaneous with the left ventricu

• In an effort to determine whether the primary

  2019-04-18

  

  In an effort to determine whether the primary tumour might be responsible for “fertilising” the bone “soil” ready for the cancer “seed”, we recently found that a hypoxic gene signature, and more specifically the secreted enzyme lysyl oxidase (LOX) was closely associated with bone metastasis, specifi

• Atrial fibrillation is the most common atrial arrhythmia stu

  2019-04-18

  

  Atrial fibrillation is the most common atrial arrhythmia studied in BrS [3–14]. The prevalence of AF has been reported to be higher in patients with BrS than in the general Ubenimex of the same age [15,16]. Earlier studies reported an approximately 10–50% prevalence of spontaneous, clinical AF in pa

• Human ether a go go related gene HERG

  2019-04-18

  

  Human-ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly-activating delayed-rectifier potassium Epoxomicin that generate IKr. This outward potassium current is elicited during the plateau phase of action potentials and is required for repolarization [4]. After being translated in th

• In our study of patients we demonstrated

  2019-04-18

  

  In our study of 24 patients, we demonstrated the highly accurate identification of PVPs by using the HDMM. These findings aligned with several other studies applying high-density mapping catheters such as either the HDMM or other comparable basket catheters [9–11]. As confirmed by the study group of

• br Meses m s tarde en Un monosindicato

  2019-04-18

  

  Meses más tarde, en “Un monosindicato que se adhiere HMBA Linker las huelgas” (, 14/enero/1935), Max Carón incluye un pliego petitorio donde delata y, a la vez, desvirtúa la profesión de su alter ego, la de traductor de cables del inglés y del francés: “Obligación de Gilberto Owen (el señor de la

• Although no GWAS results have been

  2019-04-18

  

  Although no GWAS results have been reported so far from Asian populations, the candidate gene approach identified SNPs in 4q25 and 1q21 as being associated with AF in Asian populations [19,20]. Conflicting data are reported in terms of 16q22; it is associated with AF in Chinese Han [37], but not in

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