• If the lack of specificity and

  2024-07-03

  

  If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it ibotenic acid receptor may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic interventions su

• Neuropathic animals display increased sensitivity to the ant

  2024-07-03

  

  Neuropathic animals display increased sensitivity to the anti-nociceptive effect of baclofen and whilst the number and affinity of GABAB DAMGO in the dorsal horn are not altered (Smith et al., 1994; Zemoura et al., 2016), GABAB receptors subunits (B1 and B2) are both down-regulated in sensory neuro

• Thiol are reduced by two major redox

  2024-07-03

  

  Thiol are reduced by two major redox systems, glutathione/glutaredoxin (GRX) and thioredoxin (TRX), which have been extensively studied in plants [13], [14], [15]. Glutathione, a thiol-containing tripeptide, exists in a reduced (GSH) or an oxidized form (GSSG). It has a major role as a redox buffer.

• Assessment of antibiotic appropriateness is receiving increa

  2024-07-03

  

  Assessment of antibiotic appropriateness is receiving increased attention in the face of growing concerns about the emergence of MDROs, as well as the rise in adverse outcomes associated with antibiotic use such as C. difficile infection. In this study, 15% of cultured Gram-negative organisms met th

• br Other Strategies for HIF Inhibition NSC

  2024-07-03

  

  Other Strategies for HIF-α Inhibition NSC-644221 is another HIF-α inhibitor acting at the translational level, independently of proteasomal degradation and VHL status, and is devoid of DNA damage-inducing properties [70]. NSC-644221 arrests Pertussis Toxin in G2–M through a cell type-specific To

• As noted above yeasts particularly S cerevisiae

  2024-07-03

  

  As noted above, yeasts, particularly S. cerevisiae (Frey and Röhm 1978; Trumbly and Bradley 1983), produce APs, but these are intracellular enzymes located in the vacuolar compartment, with the exception of aminopeptidase II. About 40% of aminopeptidase II activity is detected as external enzyme, li

• Histochemical analyses using antibody or cDNA

  2024-07-03

  

  Histochemical analyses using antibody or cDNA probes reveal the precise cellular location of the 12S-lipoxygenases in tissues of interest. An immunohistochemical study in various rat tissues showed specific expression of the leukocyte-type 12S-lipoxygenase in macrophages in lung and spleen [27]. In

• We start with a basic

  2024-07-03

  

  We start with a basic description of the MT-SGL model. Consider a multi-task learning (MTL) setting with k tasks. Let p be the number of covariates, shared across all the tasks, and n be the number of samples. Let denote the matrix of covariates, be the matrix of responses with each row correspondin

• Scutellaria moniliorrhiza Komarov Labiatae is a perennial he

  2024-07-03

  

  Scutellaria moniliorrhiza Komarov (Labiatae) is a perennial herb and mainly distributed in Jilin province, China. In traditional Chinese medicine, the whole plants have been used to clear away heat-evil, expel superficial evils, eliminate stasis and reduce edema (He et al., 2012). In previous phytoc

• In the past few years several experimental findings have

  2024-07-02

  

  In the past few years, several experimental findings have demonstrated a pivotal involvement of adenosine also in driving the phenotypic switch of macrophages. In particular, the stimulation of A2A and A2B receptors seems to play a critical role in switching macrophages from M1 to M2 phenotype [37,6

• We aim to evaluate the AK in regulating adenosine

  2024-07-02

  

  We aim to evaluate the AK in regulating adenosine signaling in the retina. It was reported that the degree of TC-H 106 injury directly depends on expression levels of AK and the resulting extracellular levels of adenosine (Boison, 2006). Indeed, transgenic mice overexpressing AK are highly suscepti

• substance p br Actin at presynapses br Conclusion Thanks to

  2024-07-02

  

  Actin at presynapses Conclusion Thanks to the recent discovery of rings, hotspots and trails, axonal substance p is back in the spotlight. These are exiting times for neuronal cell biologists armed with constantly improving labeling and imaging techniques to observe, quantify and perturb thes

• imipramine hcl Renal cell carcinoma RCC accounts for more th

  2024-07-02

  

  Renal cell carcinoma (RCC) accounts for more than 12,000 cancer deaths in the United States (Jemal et al., 2003). The current treatment includes surgical resection followed by interleukin-2 or Interferon-α treatment. Some patients experience distant metastatic lesions of RCC. In the last 5 years, re

• Taken together our results indicated that LOX can be

  2024-07-02

  

  Taken together, our results indicated that 5-LOX can be induced in mice by MPTP injection, and the 5-LOX inhibitor MK-886 reduced the death of dopaminergic neurons. MK-886 also reduced the LTB4 DRB australia induced by MPTP. The development of the novel 5-LOX or FLAP inhibitors may provide a new th

• The anorexic effect observed when AR is infused into

  2024-07-02

  

  The anorexic effect observed when AR231630 is infused into the VTA could be the result of the DA release inhibition, as previously described [11]. However, there is also a hedonic aspect in feeding that possibly involves dopaminergic mechanisms of reward. Helm et al. showed a functional link between

15819 records 119/1055 page Previous Next First page 上5页 116117118119120 下5页 Last page